关于过氧化苯甲酰摘要及评论
1999年第71卷第345页
美国化学文摘检索号： 94-36-0
化学文摘名称：过氧化苯甲酰
5.报告及评论摘要
5.1相关报道
据报道，过氧化苯甲酰主要用作聚合物生产的引发剂，食品漂白剂以及胶状药物中。有消费者提出在痤疮药及牙科药品中含有过氧化苯甲酰。
5.2 人体致癌性研究
少数人认为，患有恶性黑素瘤与过氧化苯甲酰有关，所以将恶性黑素瘤患者分成两组对照研究，其中一组比对照组更多地接触过氧化苯甲酰。
同时，也对痤疮药中含过氧苯甲酰来治疗痤疮病是否会导致皮肤癌进行了研究。
研究结果表明：患黑素瘤和患皮肤癌与过氧化苯甲酰没有任何关系。
5.3动物致癌性研究
在本研究中，过氧化苯甲酰被用作皮肤擦剂，分别对易感染皮肤乳状瘤的小鼠，进行皮肤涂抹试验的小鼠和将过氧化苯甲酰与致癌物结合使用的大鼠身上做试验，在其中一组试验中，老鼠身上分别产生良性的和恶性的皮肤肿瘤，而在另外一组试验中，老鼠身上产生良性肿瘤。过氧化苯甲酰对一些受试老鼠皮肤肿瘤的产生起到了促进作用。
5.4其它相关研究
过氧化苯甲酰的主要作用表现在它与大分子物质的共价结合。在抗氧化剂存在的情况下其生物学效应被终止。
过氧化苯甲酰对遗传系统的毒性很少受到注意，它对哺乳类动物细胞的DNA有损坏作用，但并未发现它诱发细菌和人工饲养的哺乳类动物的基因突变或使小鼠显性致死。
5.5 评价
没有充分的证据证明过氧化苯甲酰对人类有致癌性。
过氧化苯甲酰对动物有致癌性的证据也是有限的。
总的评价
过氧化苯甲酰对人类的致癌性并未得到官方证实。
以前的评论见：1985年第36卷及1987增刊
同义词
苯甲酸 过氧化物
过氧化苯甲酰
过氧化二苯胺
参见《毒理学》
《过氧化苯甲酰》（ICSC）
《过氧化苯甲酰》（JECFA 评价）
《食品添加剂联合专业委员会，评价》
IARC
International Agency for Research on Cancer (IARC) - Summaries & Evaluations
BENZOYL PEROXIDE
(Group 3)
For definition of Groups, see Preamble Evaluation.
VOL.: 71 (1999) (p. 345)
CAS No.: 94-36-0
Chem. Abstr. Name: Dibenzoyl peroxide
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Exposure to benzoyl peroxide may occur in its manufacture and use as an initiator in polymer production, food bleaching and rubber curing. Consumer exposure occurs from acne medications and dental products containing benzoyl peroxide.
5.2 Human carcinogenicity data
Two case control studies have evaluated exposure to benzoyl peroxide among cases of malignant melanoma. One of these studies (the smallest) (among chemists) suggested a greater frequency of exposure among cases than controls. A third large population-based case ontrol study, designed specifically to evaluate the possible risk of benzoyl peroxide used as an acne medication among young persons, included largely cases of basal-cell carcinoma of the skin. There was no association with use of benzoyl peroxide in this study.
5.3 Animal carcinogenicity data
Benzoyl peroxide was tested in two studies by skin application in strains of mice susceptible to the development of skin papillomas and in several skin-painting studies in mice and in one study in hamsters in combination with known carcinogens. In one study by skin application in mice, it induced benign and malignant skin tumours and, in the other study, benign skin tumours. Benzoyl peroxide was active as a skin tumour promoter in several strains of mice.
5.4 Other relevant data`
Benzoyl peroxide forms radicals that are involved in its covalent binding to macromolecules. Its biological effects are inhibited by antioxidants.
Its genotoxic properties have received little attention. DNA damage has been observed in treated mammalian cells, but it is not mutagenic in bacteria and does not cause chromosomal damage in cultured mammalian cells or dominant lethal effects in mice.
5.5 Evaluation
There is inadequate evidence in humans for the carcinogenicity of benzoyl peroxide.
There is limited evidence in experimental animals for the carcinogenicity of benzoyl peroxide.
Overall evaluation Benzoyl peroxide is not classifiable as to its carcinogenicity to humans (Group 3).
Previous evaluations: Vol. 36 (1985); Supplement. 7 (1987)
Synonyms
- Benzoic acid, peroxide
- Benzoperoxide
- Benzoyl superoxide
- Diphenylglyoxal peroxide
Last updated: ate Year="1999" Day="8" Month="4">8 April 1999ate>
See Als
Toxicological Abbreviations
Benzoyl peroxide (ICSC)
BENZOYL PEROXIDE (JECFA Evaluation)
